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Propranolol hydrochloride

Name: Propranolol hydrochloride
Brand: TargetMol
SKU: T0812
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0812Cas No. 318-98-9

Alias Propranolol HCl, NCS-91523, ICI-45520, AY-64043

Propranolol hydrochloride is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

Propranolol hydrochloride

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Purity: 99.94%

Catalog No. T0812Alias Propranolol HCl, NCS-91523, ICI-45520, AY-64043Cas No. 318-98-9

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$32	In Stock	In Stock
50 mg	$46	In Stock	In Stock
100 mg	$62	In Stock	In Stock
200 mg	$75	In Stock	In Stock
500 mg	$98	In Stock	In Stock
1 g	$119	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Propranolol hydrochloride is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
Targets&IC50	β-adrenoceptor:12 nM
In vitro	In cultured endothelial or tumor cells, propranolol has been shown to both reduce cAMP levels and simultaneously activate the mitogen-activated protein kinase (MAPK) pathway downstream of βAR inhibition[2]. It displays high affinity for 5-HT1B receptors (Ki= 17 nM), and milder affinity for 5HT1D receptors (Ki= 10.2 μM)[3].
In vivo	Chronic administration of propranolol increased the beta(1)-adrenoceptors but decreased the beta(2)-adrenoceptors without changing total amount of plasma membrane beta-adrenoceptors[4].
Synonyms	Propranolol HCl, NCS-91523, ICI-45520, AY-64043

Chemical Properties

Molecular Weight	295.80
Formula	C₁₆H₂₂ClNO₂
Cas No.	318-98-9
Smiles	Cl.CC(C)NCC(O)COc1cccc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (845.17 mM), Sonication is recommended.

Ethanol: <1 mg/mL

H2O: 6 mg/mL (20.28 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3807 mL	16.9033 mL	33.8066 mL	169.0331 mL
5 mM	0.6761 mL	3.3807 mL	6.7613 mL	33.8066 mL
10 mM	0.3381 mL	1.6903 mL	3.3807 mL	16.9033 mL
20 mM	0.1690 mL	0.8452 mL	1.6903 mL	8.4517 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0676 mL	0.3381 mL	0.6761 mL	3.3807 mL
100 mM	0.0338 mL	0.1690 mL	0.3381 mL	1.6903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc